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汤文强

发布时间:2017-04-18 浏览次数:0

汤文强

博士

教授、博士生导师

联系电话:0311-80787594

电子邮件:tangwq@mail.hebtu.edu.cn

所属专业:细胞生物学

工作和学习经历

1990.9-1994.6   兰州大学生物系细胞生物学专业(学士)

1994.7-1998.1   河北师范大学生物系(实习研究员)

1999.1-2004.5   美国德克萨斯大学奥斯汀分校植物系(博士)

2004.8-2009.9   美国斯坦福大学卡耐基研究院植物系(博士后)

2014.8-2015.8   美国加州大学旧金山分校药学系质谱中心(访问学者)

2010.1至今     河北师范大学生命科学学院(教授)

研究方向:

目前实验室的研究兴趣主要集中在以下两个方面:

(1)     油菜素内酯对植物生长发育调控的作用机理。

作为植物的主要生长调节激素之一,BR 在植物生长发育的各个时期都发挥着重要作用。生理学实验表明,外加BR 能诱导广普的植物生理反应,包括种子萌发,胚轴和茎的生长,木质部的分化,叶片卷曲和偏上生长(epinasty),根的生长和向重力反应,植物抗病和逆境胁迫反应等等。近年来的研究也发现通过分子生物学手段在水稻等作物不同的组织中有选择地增强或减弱内源BR的信号可以成为作物品种改良的一种新的手段和方向。

利用双子叶模式植物拟南芥为材料,对于 BR 信号转导途径的研究取得了许多突破性的进展,并得出一个基本清晰的路径图。在该路径中,BR和质膜受体BRI1结合后促进BRI1和共受体BAK1相互磷酸化,并通过质膜上蛋白激酶BSKCDG1调节下游蛋白磷酸酶BSU1的活性。BSU1将蛋白激酶BIN2去磷酸化从而抑制BIN2对转录因子BZR1/BES1的磷酸化作用。磷酸化的BZR1/BES1被蛋白磷酸酶PP2A去磷酸化,结合在DNA上,调节BR相关的基因表达。虽然目前关于BR信号传递途径的研究取得了巨大的进展,对于其中的一些关键步骤的调节机制我们了解得还是不太清楚。因此我们拟通过对这些BR上游信号传递蛋白的相互作用组(interactome)的研究来寻找它们的相互作用蛋白,同时筛选这些组分家族的T-DNA插入突变体来进一步揭示BR信号传递途径,以及BR调节植物生长发育的分子机理打下基础。

1:拟南芥中BR信号转导模式图。

2)蛋白质可逆磷酸化对植物有性生殖的调节作用机理研究。

植物有性生殖发育是一个复杂的单倍体与多倍体交替出现的过程,有性生殖使得植物对环境有了更强的适应能力,直接关系着植物物种的繁衍。植物的有性生殖涉及到雌,雄性胚子体的发育、授粉、花粉萌发,花粉管伸长和导向,双受精和合子发育等过程。我们前期通过突变体筛选的方法找到了一批参与拟南芥花粉发育,花粉管导向和种子大小等有性生殖过程调控的蛋白激酶和蛋白磷酸酶的突变体,目前在综合利用分子生物学,遗传学,细胞生物学和生物化学等手段解析这些激酶和磷酸酶作用的分子机理。对这些突变体的研究将有助于我们了解蛋白可逆磷酸化过程在植物有性生殖过程中的调节作用。

承担科研项目:

1.      农业部转基因重大专项子课题(2010, 2013-2015)

2.      “植物激素作用的分子机理”重大研究计划培育项目(2010

3.      河北省百名优秀创新人才支持计划(2010

4.      河北省留学回国基金(2010

5.      国家自然科学基金面上项目(20112017

6.      河北省杰出青年项目(2011

7.      河北省百人计划(2012

8.      “植物胚胎和种子发育的机理研究”973子课题(2014

9.      河北省高等学校创新团队陵军人才培育计划(2014)

10.  河北省应用基础研究计划重点基础研究项目(2015)

11.   “植物激素作用的分子机理”重大研究计划集成项目(2015)

承担教学任务:

1.      本科生《细胞生物学》双语课

2.      本科生《细胞生物学进展》

3.      研究生《植物信号传导》

4.      博士生《植物生长发育和信号传导机理》

所获专利:

1.      New isolated nucleic acid molecule comprising a sequence of nucleotides that encodes a brassinosteroid receptor regulated kinase useful for producing transgenic plants and modulating cellular process of a plant cell. 专利号:WO2010011285-A2; US2010043097-A1. 发明人:Wenqiang Tang and Zhiyong Wang

主要发表论文

1.      Xiaorui Yang, Yang Bai, Jianxiu Shang, Ruijiao Xin, Wenqiang Tang. (2016) The Antagonistic Regulation of Abscisic Acid-Inhibited Root Growth by Brassinosteroids is Partially Mediated via Direct Suppression of ABSCISIC ACID INSENSITIVE 5 Expression by BRASSINAZOLE RESISTANT 1. Plant, Cell & Environment 39, 1994-2003

2.      Ruiju Wang, Mengmeng Liu, Min Yuan, Juan A. Oses-Prieto, Xingbo Cai, Ying Sun, Alma Burlingame, Zhiyong Wang, Wenqiang Tang. (2016) The brassinosteroid activated BRI1 receptor kinase is switched off by dephosphorylation mediated by cytoplasm-localized PP 2A Bsubunits. Molecular Plant 9, 148-157.

3.      Baowen Zhang, Xiaolong Wang, Zhiying Zhao, Ruiju Wang, Xiahe Huang, Yali Zhu, Li Yuan, Yingchun Wang, Xiaodong Xu, Alma Burlingame, Yi Gao, Yu Sun, Wenqiang Tang. (2016) OsBRI1 activates BR signaling by preventing binding between the TPR and kinase domains of OsBSK3 via phosphorylation. Plant Physiology 170, 1149-1161.

4.      Chenmin Huo, Baowen Zhang, Hui Wang, Fawei Wang, Meng Liu, Yingjie Gao, Wenhua Zhang, Zhiping Deng, Daye Sun, Wenqiang Tang. (2016) Comparative study of early cold-regulated proteins by two dimentional difference gel electrophoresis reveals a key role for phospholipase Da 1 in mediating cold acclimation signaling pathway in rice. Molecular & Cellular Proteomics. 15, 1397-1411.

5.      Xu WangXiaolong Ma, Hui Wang, Bingjie Li, Greg Clark, Yi Guo, Stanley Roux, Daye Sun and Wenqiang Tang, (2015) Proteomic study of microsomal proteins reveals a key role for Arabidopsis Annexin 1 in mediating heat stress-induced increase in intracellular calcium levels. Molecular & Cellular Proteomics. 14, 686-694.

6.      Wenqiang Tang, (2012) Quantitative proteomic analysis of plasma membrane using two-dimensional difference gel electrophoresis (2-D DIGE). Methods in Molecular Biology 876, 67-82.

7.      Xing Liu, Jian Wu, Greg Clark, Stacey Lundy, Minhui Lim, David Arnold, Jing Chan, Wenqiang Tang, Gloria K Muday, Gary Gardner, Stanley J Roux, (2012). Role for apyrases in polar auxin transport in Arabidopsis. Plant Physiol. 160, 1985-1995

8.      Marcus A. Samuel, Wenqiang Tang, Muhammad Jamshed, Julian Northey, Darshan Patel, Daryl Smith, Michael Siu, Douglas G Muench, Zhi-Yong Wang, and Daphne R. Goring. (2011) Proteomic analysis of Brassica stigmatic proteins following the self-incompatibility reaction reveals a role for microtubule dynamics during pollen responses. Mol Cell Proteomics 10, M111.011338, 113.

9.      Wenqiang Tang*, Min Yuan*, Ruiju Wang*, Yihong Yang*, Chunming Wang, Juan A. Oses-Prieto, Tae-Wuk  Kim, Hong-Wei Zhou, Zhiping Deng, Srinivas S. Gampala, Joshua M. Gendron, Else M. Jonassen, Cathrine Lillo, Alison DeLong, Alma L. Burlingame, Ying Sun & Zhi-Yong Wang. (2011) PP 2A activates brassinosteroid responsive gene expression and plant growth by dephosphorylating BZR1. Nature Cell Biology 13, 124-131. (*equal contribution)

10.  Wenqiang Tang, Zhiping Deng and Zhi-Yong Wang. (2010) Proteomics shed light on the brassinosteroid signaling mechanism. Curr Opin. Plant Biol. 13, 27-33.

11.  Yu Sun, Xi-Ying Fan, Dong-Mei Cao, Wenqiang Tang, Kun He, Jia-Ying Zhu, Jun-Xian He, Ming-Yi Bai, Shengwei Zhu, Eunkyoo Oh, Sunita Patil, Tae-Wuk Kim, Hongkai Ji, Wing Hong Wong, Seung Y. Rhee, Zhi-Yong Wang. (2010) Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis. Development Cell 19, 765-777.

12.  Tae-Wuk Kim, Shenheng Guan, Yu Sun, Zhiping Deng, Wenqiang Tang, Jian-Xiu Shang, Ying Sun, Alma L. Burlingame and Zhi-Yong Wang. (2009) Brassinosteroid signal transduction from cell-surface receptor kinases to nuclear transcription factors. Nature Cell Biology 11, 1254-1262.

13.  Wenqiang Tang, Tae-Wuk Kim, Juan A Oses-Prieto, Yu Sun, Zhiping Deng, Shengwei Zhu, Ruiju Wang, Alma L. Burlingame, and Zhi-Yong Wang (2008) BSKs mediate signal transduction from the receptor kinase BRI 1 in Arabidopsis. Science 321, 557-560.

14.  Wenqiang Tang, Zhiping Deng, Juan A. Oses-Prieto, Nagi Suzuki, Shengwei Zhu, Xin Zhang, Alma L. Burlingame, and Zhi-Yong Wang (2008) Proteomic studies of brassinosteroid signal transduction using prefractionation and 2-D DIGE. Mol Cell Proteomics 7, 728-738.

15.  Srinivas S. Gampala, Tae-Wuk Kim, Jun-Xian He, Wenqiang Tang, Zhiping Deng, Mingyi-Yi Bai, Shenheng Guan, Sylvie Lalonde, Ying Sun, Joshua M. Gendron, Huanjing Chen, Nakako Shibagaki, Robert J. Ferl, David Ehrhardt, Kang Chong, Alma L. Burlingame and Zhi-Yong Wang. (2007) An Essential Role for 14-3-3 Proteins in Brassinosteroid Signal Transduction in Arabidopsis. Developmental Cell 13, 177-189

16.  Collene R. Jeter*, Wenqiang Tang*, Elizabeth Henaff, Tim Butterfield, and Stanley J. Roux.  (2004) Evidence of a Novel Cell Signaling Pathway in Arabidopsis Induced by Extracellular Nucleoside Tri- and Diphosphates. Plant Cell 16, 2652- 2664 (*equal contribution)

17.  Wenqiang Tang., Shari R. Brady, Yu Sun., Gloria K. Muday, and Stanley J. Roux (2003) Extracellular ATP Inhibits Root Gravitropism at Concentrations That Inhibit Polar Auxin Transport. Plant Physiology 131, 147-154

全国和国际会议报告:

1.      第二届全国植物逆境生物学学术研讨会,青岛,20165

2.      International Conference of the Genetics Society of Korea, Seoul, 201512

3.      全国植物生物学大会,南京,201310

4.      全国遗传学会第九次全国代表大会,哈尔滨,20139

5.      4th Internation Symposium on Frontier in Agriculture Proteome Research, Wuhan, China, 201211

6.      全国植物生物学大会, 杨陵,201210


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