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贺进田

发布时间:2017-04-18 浏览次数:0

贺进田

博士 副教授、 硕士生研究生导师

联系电话:80787570

电子邮件:he_jintian@sina.com

个人网页:

所属专业:生物化学与分子生物学

学习经历:

2005年,复旦大学医学院生物化学与分子生物学专业,博士

1996年,南开大学化学系攻读硕士研究生,硕士

1990年,河北大学化学系物理化学专业,学士

主要教学科研工作:1996年-2002年,在石家庄制药集团研究所工作,主要从事微生物药物的研发;2005年,进入河北师范大学生命科学学院工作,主讲《微生物学》和《微生物学实验》等本科生专业课程,研究方向是生物技术药物新型制剂研究,实验室工作主要集中在生物药物的缓释、控释和靶向微米和纳米颗粒给药系统的研制,已经培养十余名硕士研究生。主持河北省自然基金、河北省科技支撑计划项目、河北省教育厅重点资助项目等多项科研项目。在International Journal of PharmaceuticsActa Pharmacologica SinicaJournal of MicroencapsulationActa Biochimica et Biophysica SinicaBiotechnology and Applied Biochemistry、药学学报、中国药学杂志、微生物学报等国内、外重要学术期刊上发表论文二十余篇。申请国家发明专利6项,授权5项。

发表的论文:

1. Jintian He*, Feng M, Zhou X, Ma Sh, Jiang Y, Wang Y, Zhang H.Stabilization and encapsulation of recombinant human erythropoietin into PLGAmicrospheres using human serum albumin as a stabilizer [J]. Int J Pharm 2011,416: 6976. (SCI,IF3.607)

2Xiang-lian ZHOU, Jin-tian HE*(corresponding author), Hui-juan DU, Yang-yang FAN, Ying WANG, Hong-xiaZHANG, Yang JIANG, Pharmacokinetic and pharmacodynamic profiles of recombinanthuman erythropoietin-loaded poly(lactic-co-glycolic acid) microspheres in rats[J]. Acta Pharmacol Sin. 201233: 137144. (SCI, IF2.35)

3Jintian He*, Zhitao Zhou, YangyangFan, Xianglian Zhou, Huijuan Du, Sustained release of low molecular weightheparin from PLGA microspheres prepared by a solid-in-oil-in-water emulsionmethod. Journal of Microencapsulation, 2011, 28(8): 763770. (SCI, IF1.515)

4. Jintian He*, Ruiguang Xu, Xi Chen, Kai Jia, Xianglian Zhou, and KeZhu. Simultaneous elimination of T- and B-cell epitope by structure-basedmutagenesis of single Glu80 residue within recombinant staphylokinase [J]. ActaBiochim Biophys Sin, 2010: 209215. SCIE

5Jintian He*, Gaizhen Wang, RuiguangXu, Jinlin Feng, Huabo Su, Houyan Song. Refolding of a staphylokinase variantY1-Sak by reverse dilution. Applied Biochemistry and Biotechnology. 2008,151:29~41.

6Jintian He*, Ruiguang Xu, Xi Chen, KaiJia, Xianglian Zhou, and Ke Zhu. Simultaneous elimination of T- and B-cellepitope by structure-based mutagenesis of single Glu80 residue withinrecombinant staphylokinase. Acta Biochim Biophys Sin, 2010: 209215. SCIE

7. Jin-Tian He, Hua-Bo Su, Guo-Ping Li, Xian-Mei Tao, Wei Mo, Hou-Yan.Stabilization and encapsulation of a staphylokinase variant (K35R) intopoly(lactic-co-glycolic acid) microspheres. International Journal ofPharmaceutics 2006, 309 (1-2): 101108. SCI, IF: 2.156

8.Jintian He, Gaizhen Wang, Guoping Li, Baohua Zhao, Wei Mo, HouyanSong. Purification and characterization of a staphalokinase variant K35R.Biotechnology and Applied Biochemistry. 200645 (part 1): 43-49. SCI, IF: 1.89

9. Jintian He, Jingfang Di, Ruiguang Xu and Baohua Zhao. Novelrecombinant thrombolytic and antithrombotic staphylokinase variants with RGDmotif at their N-terminus. Biotechnology and Applied Biochemistry. 2008, 50(Pt1):17-23.

10. Ruiguang Xu, Jintian He* (corresponding author), Kai Jia, Xi Chen,Jianwei Liu, Ke Zhu. Simultaneous removal of T and B cell epitope inrecombinant staphylokinase by structure-based mutagenesis of immuno-dominantArg77 and Glu80 residues. 微生物学报, 201151(5)692~703.

专利:

1、一种低免疫原性葡激酶突变体及其制备方法和应用;发明专利;发明人:贺进田,徐瑞光,陈希,贾锴; 授权时间2013

2、含重组人促红细胞生成素的缓释微球制剂、制备方法和用途;发明专利;发明人:贺进田,冯美彦,姜杨,梁倩;授权时间2012

3、具有抗血小板聚集和纤溶活性的双功能葡激酶突变体、应用及其制备方法;发明专利;发明人:贺进田,徐瑞光,狄静芳;授权时间2010

4、含葡激酶突变体的缓释微球制剂及其制备方法;发明专利;发明人:贺进田,宋后燕;授权时间2007

5、一种运动保健食品;发明专利;发明人:贺进田,王慧嫱,郭立中;授权时间2006


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