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汤文强

发布时间:2017-04-18

           

汤文强博士

教授博士生导师

联系电话0311-80787594

电子邮件tangwq@mail.hebtu.edu.cn

所属专业:细胞生物学


工作和学习经历

1990.9-1994.6兰州大学生物系细胞生物学专业  学士

1994.7-1998.1   河北师范大学生物系  实习研究员

1999.1-2004.5美国德克萨斯大学奥斯汀分校植物系  博士

2004.8-2009.9美国斯坦福大学卡耐基研究院植物系  博士后

2014.8-2015.8   美国加州大学旧金山分校药学系质谱中心  访问学者

2010.1至今河北师范大学生命科学学院  教授

研究方向:

目前实验室的研究兴趣主要集中在以下两个方面:

(1)    油菜素内酯对植物生长发育调控的作用机理

作为植物的主要生长调节激素之一,BR 在植物生长发育的各个时期都发挥着重要作用。生理学实验表明,外加BR 能诱导广普的植物生理反应,包括种子萌发,胚轴和茎的生长,木质部的分化,叶片卷曲和偏上生长(epinasty),根的生长和向重力反应,植物抗病和逆境胁迫反应等等。近年来的研究也发现通过分子生物学手段在水稻等作物不同的组织中有选择地增强或减弱内源BR的信号可以成为作物品种改良的一种新的手段和方向。

利用双子叶模式植物拟南芥为材料,对于BR 信号转导途径的研究取得了许多突破性的进展,并得出一个基本清晰的路径图。在该路径中,BR和质膜受体BRI1结合后促进BRI1和共受体BAK1相互磷酸化,并通过质膜上蛋白激酶BSKCDG1调节下游蛋白磷酸酶BSU1的活性。BSU1将蛋白激酶BIN2去磷酸化从而抑制BIN2对转录因子BZR1/BES1的磷酸化作用。磷酸化的BZR1/BES1被蛋白磷酸酶PP2A去磷酸化,结合在DNA上,调节BR相关的基因表达。虽然目前关于BR信号传递途径的研究取得了巨大的进展,对于其中的一些关键步骤的调节机制我们了解得还是不太清楚。因此我们拟通过对这些BR上游信号传递蛋白的相互作用组interactome的研究来寻找它们的相互作用蛋白,同时筛选这些组分家族的T-DNA插入突变体来进一步揭示BR信号传递途径,以及BR调节植物生长发育的分子机理打下基础。

1:拟南芥中BR信号转导模式图

2)植物热激信号传导机理。

随着人类工业化进程的加剧,温室效应导致的全球温度升高是一个不争的事实。最近30多年来,全球平均温度已经升高了近1度。统计学研究发现全球平均温度每升高1度,将导致水稻减产3.2%,玉米减产7.4%,大豆减产3.1%,小麦减产6%。因此研究植物抵抗高温的分子机制将有利于开发重要植物耐热标记基因,帮助培育高产耐热作物新品种,具有重要的理论和生产应用价值。我实验室主要关注植物如何感受环境高温的变化,并调节基因表达来提高植物耐热性的早期热激信号传导机制。目前的工作主要集中于建立早期热激信号被激活的分子评估体系,寻找新的早期信号传导组分,并解析植物早期热激记忆形成的分子机制。

承担科研项目:

1.    国家自然科学基金面上项目(2011-2013,2017-2020, 2019-2022, 2021-2024

2.    植物胚胎和种子发育的机理研究”973子课题(2014-2018

3.    植物激素作用的分子机理重大研究计划培育和集成项目(2010-20122015

4.    农业部转基因重大专项子课题(2010, 2013-2015)

5.    河北省百名优秀创新人才支持计划(2010-2012

6.    河北省留学回国基金(2010-2012

7.    河北省杰出青年项目(2011-2013

8.     河北省百人计划(2012-2016

9.    河北省高等学校创新团队领军人才培育计划(2014-2016)

10.  河北省应用基础研究计划重点基础研究项目(2015-2017)

11.  河北省自然科学基金重点项目(2020-2022

承担教学任务:

1.     本科生《细胞生物学》双语课

2.     本科生《细胞生物学进展》

3.     本科生《生命科学进展》

4.     研究生《植物信号传导》

5.     博士生《植物生长发育和信号传导机理》

所获专利:

1.     “Newisolated nucleic acid molecule comprising a sequence of nucleotides thatencodes a brassinosteroid receptor regulated kinase useful for producingtransgenic plants and modulating cellular process of a plant cell”. 专利号:WO2010011285-A2;US2010043097-A1. 发明人:Wenqiang Tang and Zhiyong Wang

2.    "水稻基因BSK3的应用”,专利号(ZL201410832924.8), 申请日:2014/12/29;授权日:2017/11/14;发明人:汤文强、张宝文

3.    水稻敏热基因UBP21的应用,专利号(ZL201410745025.4), 申请日:2014/12/09;授权日:2018/9/18;发明人:汤文强、张宝文、安志超

4.    “GBP蛋白及其编码基因在调控植物产量中的应用”,专利号(ZL201710532910.8),申请日:2017/7/3;授权日:2020/12/29;发明人:汤文强、安志超、张宝文

所获奖励:

1.  “油菜素内信号传导及其控植物生长发育的分子机制”2020年度河北省科学技术奖(自然科学)一等

主要发表论文

1.     RuijuWang, Ruixuan Wang, Mengmeng Liu, Weiwei Yuan, Zhiying Zhao, Xiaoqian Liu,Yameng Peng, Xiaorui Yang, Yu Sun, WenqiangTang* (2021) Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT 1 in Arabidopsis thaliana. Proc. Natl.Acad. Sci. U.S.A. 118(33):e2101838118

2. Zhiying Zhao,Sha Tang, Wei Li, Xiaorui Yang, Ruiju Wang, XianminDiao*, Wenqiang Tang*(2021) Overexpressionof a BRASSINAZOLE RESISTANT 1 homolog attenuates drought tolerance bysuppressing the expression of PLETHORA-LIKE 1 in Setariaitalica. CropJ. 9(5):1208-1213

3.     ZhiyingZho, Sha Tang, Yiming Zhang, Jingjing Yue,Jiaqi Xu, Wenqiang Tang, Yanxiang Sun, Ruiju Wang, XianminDiao*, Baowen Zhang*(2021) Evolutionary analysis and functional characterization of SiBRI1 as abrassinosteroid receptor gene in foxtail millet. BMC Plant Biology 21:291

4. Xiaojie Tian, Mingliang He,EnyangMei,Baowen Zhang, Jiaqi Tang, Min Xu, Jiali Liu, Xiufeng Li, Zhenyu Wang,Wenqiang Tang, Qingyun Bu* (2021)WRKY53 Integrates Classic Brassinosteroid Signaling and the Mitogen-ActivatedProtein Kinase Pathway to Regulate Rice Architecture and Seed Size. PlantCell (DOI: 10.1093/plcell/koab137)

5.     Meicheng Zhao, Sha Tang,HaoshanZhang, MiaomiaoHe, JihongLiu, Hui Zhi, Yi Sui, xiaotongLiu, GuanqingJia,ZhiyingZhao, JijunYan, BaocaiZhang, YihuaZhou, JinfangChu, XingchunWang, BaohuaZhao,WenqiangTang, Jiayang Li, CHuanyinWu, XigangLiu and XianminDiao (2020)DROOPYLEAF1 controls leaf architecture by orchestrating early brassinosteroidsignaling. Proc. Natl. Acad. Sci. U.S.A.117(35):21766-21774

6.     DandanJia, Lian-Ge Chen,Guimin Yin, Xiaorui Yang, Zhihua Gao, Yi Guo, Yu Sun and Wenqiang Tang*(2020) Brassinosteroids regulate outer ovule integument growth in part via thecontrol of INNER NO OUTER by BRASSINOZOLE-RESISTANT family transcriptionfactors. J Integr Plant Biol. 62(8):1093-1111(Cover story)

7.    Bingjie Li, Zhihua Gao, Xinye Liu, DayeSun, Wenqiang Tang* (2019) TranscriptionalProfiling Reveals a Time-of-Day-Specific Role of REVEILLE 4/8 in Regulating theFirst Wave of Heat Shock–Induced Gene Expression in Arabidopsis. PlantCell 31: 2353-2369

8.    Hangfan Zhou, Xiaolong Wang, ChenminHuo,Hui Wang, Zhichao An, Daye Sun, Jingze Liu, Wenqiang Tang* and BaowenZhang* (2019) A Quantitative Proteomics Study of EarlyHeat-RegulatedProteins by Two-Dimensional Difference GelElectrophoresisIdentified OsUBP21 as a Negative Regulator of HeatStressResponses in Rice. Proteomics19:e1900153(*co-corresponding authors, Cover story)

9.    Liange Chen, Zhihua Gao, Zhiying Zhao,Xinye Liu, Yongpeng Li, Yuxiang Zhang, Xigang Liu, Yu Sun and Wenqiang Tang* (2019) BZR1 FamilyTranscription Factors FunctionRedundantly and Indispensably in BR SignalingbutExhibit BRI1-Independent Function inRegulating Anther Development inArabidopsis. Molecular Plant 12: 1408-1415

10.  ZhihuaGao, Zhiying Zhao, Wenqiang Tang*(2018) DREAMSeq: an improved method for analyzing differentially expressedgenes in RNA-seq data. Frontiers inGenetics9:588

11.  BingjieLi, Kang Gao, Huimin Ren and WenqiangTang*. (2018) Molecular mechanisms governing plant responses to hightemperatures. J Integr Plant Biol. 60(9):757-779(Invited Expert Review)

12.  ZhichaoAn, Yuliang Liu, Yang Ou, Jia Li, Baowen Zhang, Daye Sun, Yu Sun*, WenqiangTang *. (2018) Regulation of the stability of RGF1 receptor by theubiquitin-specific proteases UBP12/UBP13 is critical for root meristemmaintenance. Proc. Natl. Acad. Sci. U.S.A. 115(5):1123-1128 (* co-corresponding authors)

13.  霍晨敏、汤文强 (2016) 植物冷信号传导机制研究进展生物技术通报10:27-33 (特约综述)

14.  XiaoruiYang, Yang Bai, Jianxiu Shang, Ruijiao Xin, Wenqiang Tang*. (2016) The Antagonistic Regulation of AbscisicAcid-Inhibited Root Growth by Brassinosteroids is Partially Mediated via DirectSuppression of ABSCISIC ACID INSENSITIVE 5 Expression by BRASSINAZOLE RESISTANT1. Plant,Cell & Environment39(9):1994-2003

15.  RuijuWang, Mengmeng Liu, Min Yuan, Juan A. Oses-Prieto, XingboCai, Ying Sun, AlmaBurlingame, Zhiyong Wang, Wenqiang Tang*. (2016) The brassinosteroidactivated BRI1 receptor kinase is switched off by dephosphorylation mediated bycytoplasm-localized PP2A B’ subunits. Molecular Plant9(1):148-157.

16.  BaowenZhang, Xiaolong Wang, Zhiying Zhao, Ruiju Wang, Xiahe Huang, Yali Zhu, Li Yuan,Yingchun Wang, Xiaodong Xu, Alma Burlingame, Yi Gao, Yu Sun, Wenqiang Tang*.(2016) OsBRI1 activates BR signaling by preventing binding between the TPR andkinase domains of OsBSK3 via phosphorylation. Plant Physiology 170(2):1149-1161.

17.  ChenminHuo,Baowen Zhang, Hui Wang, Fawei Wang, Meng Liu, Yingjie Gao, Wenhua Zhang, ZhipingDeng, Daye Sun, Wenqiang Tang*. (2016) Comparative study of earlycold-regulated proteins by two dimentional difference gel electrophoresisreveals a key role for phospholipase Da1 in mediating cold acclimationsignaling pathway in rice. Molecular & Cellular Proteomics15(4):1397-1411.

18.  XuWangXiaolongMa, Hui Wang, Bingjie Li, Greg Clark, Yi Guo, Stanley Roux, Daye Sun andWenqiangTang*,(2015) Proteomic study of microsomal proteins reveals a key role forArabidopsis Annexin 1 in mediating heat stress-induced increase inintracellular calcium levels. Molecular & Cellular Proteomics14(3):686-694.

19.  PengXu, Shouling Xu, Zijing Li, WenqiangTang, Alma L. Burlingame and Zhiyong Wang (2014) A brassinosteroidsignaling kinase interacts with multiple receptor-like kinases in Arabidopsis. MolecularPlant7(2):441-444.

20.  Wenqiang Tang*(2012) Quantitative proteomic analysis ofplasma membrane using two-dimensional difference gel electrophoresis (2-DDIGE). Methods in Molecular Biology876:67-82.

21.  Xing Liu,Jian Wu, Greg Clark, Stacey Lundy, MinhuiLim, David Arnold, Jing Chan, WenqiangTang,Gloria KMuday, Gary Gardner, Stanley J Roux, (2012). Role for apyrases in polarauxin transport in Arabidopsis. Plant Physiology160(4):1985-1995

22.  MarcusA. Samuel, Wenqiang Tang, Muhammad Jamshed, Julian Northey, DarshanPatel, Daryl Smith, Michael Siu, Douglas G Muench, Zhi-Yong Wang, and Daphne R.Goring. (2011) Proteomic analysis of Brassica stigmatic proteins following theself-incompatibility reaction reveals a role for microtubule dynamics duringpollen responses. Molecular & Cellular Proteomics10(12):M111.011338.

23. WenqiangTang*,Min Yuan*, Ruiju Wang*, Yihong Yang*, Chunming Wang, Juan A. Oses-Prieto,Tae-Wuk  Kim, Hong-Wei Zhou, ZhipingDeng, Srinivas S. Gampala, Joshua M. Gendron, Else M. Jonassen, Cathrine Lillo,Alison DeLong, Alma L. Burlingame, Ying Sun&Zhi-Yong Wang. (2011) PP2Aactivates brassinosteroidresponsive gene expression and plant growth bydephosphorylating BZR1. Nature Cell Biology13(2):124-131. (*equal contribution)

24.  Wenqiang Tang, Zhiping Deng and Zhi-Yong Wang. (2010) Proteomics shed light onthe brassinosteroid signaling mechanism.Current Opinion in Plant Biology13(1):27-33.

25.  YuSun, Xi-Ying Fan, Dong-Mei Cao, Wenqiang Tang, Kun He, Jia-Ying Zhu,Jun-Xian He, Ming-Yi Bai, Shengwei Zhu, Eunkyoo Oh, SunitaPatil, Tae-Wuk Kim,Hongkai Ji, Wing Hong Wong, Seung Y. Rhee, Zhi-Yong Wang. (2010) Integration ofBrassinosteroid Signal Transduction with the Transcription Network for PlantGrowth Regulation in Arabidopsis.Development Cell19(5):765-777.

26.  Tae-WukKim, Shenheng Guan, Yu Sun, Zhiping Deng, WenqiangTang, Jian-Xiu Shang, Ying Sun, Alma L. Burlingame and Zhi-Yong Wang.(2009) Brassinosteroid signal transduction from cell-surface receptor kinasesto nuclear transcription factors. Nature Cell Biology11(10):1254-1262.

27.  Wenqiang Tang,Tae-Wuk Kim, Juan A Oses-Prieto,YuSun, Zhiping Deng, Shengwei Zhu, Ruiju Wang, Alma L. Burlingame, andZhi-Yong Wang (2008) BSKs mediate signal transduction from the receptor kinaseBRI1 in Arabidopsis. Science321(5888):557-560.

28.  Wenqiang Tang,Zhiping Deng, Juan A. Oses-Prieto, Nagi Suzuki, Shengwei Zhu, Xin Zhang, AlmaL. Burlingame, and Zhi-Yong Wang (2008) Proteomicstudies of brassinosteroid signal transduction using prefractionation and 2-DDIGE. Molecular & Cellular Proteomics7(4):728-738.

29.  ZhipingDeng, Xing Zhang, Wenqiang Tang, Juan A.Oses-Prieto, Nagi Suzuki, Joshua MGendron, Huanjing Chen, Shenheng Guan, Robert J. Chalkley, T. Kaye Peterman,Alma L. Burlingame and Zhiyong Wang. (2007) A proteomic study ofbrassinosteroid response in Arabidopsis. Molecular & CellularProteomics6(12):2058-2071

30.  SrinivasS. Gampala, Tae-Wuk Kim, Jun-Xian He, WenqiangTang, Zhiping Deng, Mingyi-Yi Bai, Shenheng Guan, Sylvie Lalonde, Ying Sun,Joshua M. Gendron, Huanjing Chen, NakakoShibagaki, Robert J. Ferl, DavidEhrhardt, Kang Chong, Alma L. Burlingame and Zhi-Yong Wang. (2007) An Essential Role for 14-3-3 Proteins in BrassinosteroidSignal Transduction in Arabidopsis. Developmental Cell13(2):177-189

31.  ColleneR. Jeter*, Wenqiang Tang*, Elizabeth Henaff, Tim Butterfield, andStanley J. Roux.  (2004) Evidence ofa Novel Cell Signaling Pathway in Arabidopsis Induced by ExtracellularNucleoside Tri- and Diphosphates. Plant Cell 16, 2652-2664 (*equalcontribution)

32.  WenqiangTang.,Shari R. Brady, Yu Sun., Gloria K. Muday, and Stanley J. Roux (2003) Extracellular ATP Inhibits Root Gravitropism atConcentrations That Inhibit Polar Auxin Transport. Plant Physiology131, 147-154

全国和国际会议报告:

1.  第七届全国植物蛋白质研究大会”,济南,201811

2.    “2018 World life conference”, 北京,201810

3.    “The 3rd International BrassinosteroidConference”, San Diego, 20188

4.    “University of Texas Cell SignalingSymposium 2017”, Austin, TX, 20177

5.    “International Plant Receptor-likekinase symposium 2017), 兰州,20175

6.     全国植物生物学大会, 武汉,201610

7.     海峡两岸植物生物学青年科学家论坛,杭州,20169

8.     第二届全国植物逆境生物学学术研讨会,青岛,20165

9.    International Conference of the GeneticsSociety of Korea, Seoul, 201512

10.  全国植物生物学大会,南京,201310

11.  全国遗传学会第九次全国代表大会,哈尔滨,20139

12.  4thInternationSymposium on Frontier in Agriculture Proteome Research, Wuhan, China, 201211

13.  全国植物生物学大会, 杨陵,201210

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