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A Primary Study of the Antioxidant, Hypoglycemic,Hypolipidemic, and Antitumor Activities of Ethanol Extract of Brown Slimecap Mushroom, Chroogomphusrutilus (Agaricomycetes)

发布时间：2017-12-20

Jinxiu Zhang, Xiaojing Zhao, Li Qiang Zhao, Junxia Zhao, Zhiguang Qi, & Li-An Wang*

International Journal of Medicinal Mushrooms

2017, pages 905-913, DOI: 10.1615/IntJMedMushrooms.2017024564  

ABSTRACT: In vivo and in vitro treatments were carried out to investigate the effects of a 95% ethanol extract of Chroogomphus rutilus (CRE) on antioxidant, hypoglycemic, hypolipidemic, and antitumor properties. CRE showed potent radical scavenging activity against DPPH in vitro. It could increase antioxidant enzymatic activities (superoxide dismutase and glutathione peroxidase) and could reduce malondialdehyde content in vivo in mice in which aging was induced by d-galactose. CRE had hypoglycemic activity and could significantly inhibit α-glucosidase activity in vitroand decrease blood glucose concentration in vivo. CRE could decrease the serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels and increase the high-density lipoprotein cholesterol level in diabetic mice. The MTT assay showed that CRE also had a certain inhibitory effect on the tumor cells. These results suggest that CRE may be beneficial for human health and could be useful for applications in medicine, the food industry, and agriculture.

KEY WORDS: antioxidant enzymes, biological activity, cytotoxicity, Chroogomphus rutilus, medicinal mushrooms

附件1：IJM1910-05-24564