当前位置:首页>>教师信息 教师信息

曹鹏秀

发布时间:2018-09-14 浏览次数:0

曹鹏秀,博士

河北师范大学“精英计划”引进人才

河北省第八批“百人计划”省级特聘专家

联系电话:0311-80787586

电子邮件:caopx@mail.hebtu.edu.cn

所属专业:生理学


主要学习和工作经历:

1998-2002  河北师范大学生命科学学院                                       获得理学学士学位

2002-2007   中国科学院遗传与发育生物学研究所                         获得理学博士学位

2008-2017 美国CaseWestern Reserve University、Cleveland

Clinic和Universityof Michigan 等高校或研究所                           进行博士后研究

2018-今    河北师范大学                                                              讲师


主要教学科研工作:

教学: 担任国家级精品资源共享课《组织学与解剖学》主讲教师。主讲课程:《组织学与解剖学》、《组织学与解剖学实验》和《生物信息学》。

研究方向:(1) 铁代谢影响肺纤维化进程分子机制研究及有效治疗策略和药物的开发及筛选;(2) 雾霾引起肺部重塑的机制研究和干预策略;(3) 吸烟致肺部疾病机制研究及分子治疗策略。


代表性研究论文:

1. Cao Pengxiu*, Aoki Yoshiro*,  Badri  Linda,  Walker Natalie M.,  Manning  Casey M.,  Lagstein  Amir,  Fearon  Eric R.,  Lama  Vibha N. (2017) Autocrine lysophosphatidic acidsignaling activates β-catenin and promotes lung allograft fibrosis. Journal of Clinical Investigation, 127(4):1517-1530. *Contribute equally.

2. Chen  Shenghan,  Cao  Pengxiu,  Dong  Ningzheng,  Peng  Jianhao,  Zhang  Chunyi,  Wang  Hao,  Zhou  Tiantian,  Yang  Junhua,  Zhang  Yue,  Martelli  Elizabeth E.,  Prasad  Sathyamangla V. Naga,  Miller  Rachel E.,  Malfait  Anne-Marie,  Zhou  Yiqing,  Wu  Qingyu. (2015) PCSK6-mediated corin activation is essentialfor normal blood pressure. NatureMedicine, 21(9):1048-1053.

3. Cao  Pengxiu*,  Sun  Wenyu*,  Kramp  Kristopher,  Zheng  Maohua,  Salom  David,  Jastrzebska  Beata,  Jin  Hui,  Palczewski  Krzysztof,  Feng  Zhaoyang. (2012) Light-sensitive coupling of rhodopsinand melanopsin to Gi/o and Gq signal transduction in Caenorhabditis elegans.FASEB J., 26(2):480-491. *Contribute equally.

4. Salom  David*,  Cao  Pengxiu*,  Sun  Wenyu*,  Kramp  Kristopher,  Jastrzebska  Beata,  Jin  Hui,  Feng  Zhaoyang,  Palczewski  Krzysztof. (2012) Heterologous expression of functionalG-protein-coupled receptors in Caenorhabditis. FASEB J., 26(2):492-502. *Contribute equally.

5. Cao  Pengxiu*,  Yuan  Yiyuan*,  Pehek  Elizabeth A.,  Moise  Alex R.,  Huang  Ying,  Palczewski  Krzysztof,  Feng  Zhaoyang. (2010) Alpha-synuclein disrupted dopaminehomeostasis leads to dopaminergic neuron degeneration in Caenorhabditiselegans. PLoS ONE, 5 (2), e9312. doi:10.1371/journal.pone.0009312. *Contributeequally.

6. Cao  Pengxiu,  Song  Jian,  Zhou  Chunjiang,  Weng  Manli,  Liu  Jing,  Wang  Fuxin,  Zhao  Feng,  Feng  Dianqi,  Wang  Bin. (2009) Characterization of multiple coldinduced genes from Ammopiptanthus mongolicus and functional analyses of geneAmEBP1. Plant Molecular Biology, 69(5), 529-539.

7. Fei Y.B.*, Cao P.X.*, Gao S.Q., Wang B., Wei L.B.,Zhao J., Chen G.& Wang B.H. (2008) Purification and analysis of antifreezeproteins from a ligneous plant. Preparative Biochemistry and Biotechnology, 38(2), 172- 183. *Contribute equally.

8. Fei Y.B.*, Cao P.X.*, Gao S.Q., Wei L.B. &Wang B. (2005) Discovery of a homolog of siderophilin in a plant. Journal ofIntegrative Plant Biology, 47 (12), 1409-1411. *Contribute equally.

9. Chen  Yuanyuan,  Jastrzebska  Beata,  Cao  Pengxiu,  Zhang  Jianye,  Wang  Benlian,  Sun  Wenyu,  Yuan  Yiyuan,  Feng  Zhaoyang,  Palczewski  Krzysztof. (2014) Inherent instability of the retinitispigmentosa P23H mutant opsin. The Journal of Biological Chemistry, 289(13):9288-9303.

10. Yuan Yiyuan,  Hakimi Parvin,  Kao Clara,  Kao Allison,  Liu Ruifu,  Janocha Allison,  Boyd-Tressler Andrea,  Hang Xi,  Alhoraibi Hanna,  Slater Erin,  Xia Kevin,  Cao Pengxiu,  Shue Quinn,  Ching Tsui-Ting,  Hsu Ao-Lin,  Erzurum Serpil C.,  Dubyak George R.,  Berger Nathan A.,  Hanson RichardW.,  Feng Zhaoyang. (2016) Reciprocal Changes inPhosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are aDeterminant of Aging in Caenorhabditis elegans. The Journal of Biological Chemistry, 291(3):1307-1319.

11. Yuan  Yiyuan,  Cao  Pengxiu,  Smith  Mark A.,  Kramp  Kristopher,  Huang  Ying,  Hisamoto  Naoki,  Matsumoto  Kunihiro,  Hatzoglou  Maria,  Jin  Hui,  Feng  Zhaoyang. (2011) Dysregulated LRRK2/p38 signaling inresponse to endoplasmic reticulum stress leads todopaminergic neuron degeneration. PLoS ONE, 6 (8):e22354.

12. Salom  David,  Cao  Pengxiu,  Yuan  Yiyuan,  Miyagi  Masaru,  Feng  Zhaoyang,  Palczewski  Krzysztof. (2015) Isotopic labeling of mammalian GPCRs heterologously expressed inCaenorhabditis elegans. Accepted in Anal Biochem., 2015,472:30-36.

13. Zheng  Maohua,  Cao  Pengxiu,  Yang  Jiong,  Xu  X. Z. Shawn,  Feng  Zhaoyang. (2012) Calcium imaging of multiple neuronsin freely behaving C. elegans. Journal of Neuroscience Methods. 206 (1), 78–82.

14. Jastrzebska  Beata,  Salom  David,  Jin  Hui,  Cao  Pengxiu,  Sun  Wenyu,  Palczewski  Krzysztof,  Feng  Zhaoyang. (2013) Expression of mammalian Gprotein-coupled receptors in Caenorhabditis elegans. Methods in Enzymology.520:239-256.

15. Zhou  Chunjiang,  Chen  Cuixia,  Cao  Pengxiu,  Wu  Suowei,  Sun  Jianwei,  Jin  Demin,  Wang  Bin. (2007). Characterization and fine mapping of RppQ, aresistance gene to southern corn rust in maize. Molecular Genetics andGenomics, 278 (6), 723-728.

16. Song  Jian,  Liu  Jing,  Weng  Manli,  Huang  Yanyan,  Luo  Lei,  Cao  Pengxiu,  Sun  Haiwei,  Liu  Jie,  Zhao  Jinhong,  Feng  Dianqi,  Wang  Bin. (2013) Cloning of Galactinol Synthase Gene fromAmmopiptanthus Mongolicus and its expression in transgenic Photinia serrulataplants. Gene. 15, 513(1):118-127.

17. Liang F., Kong F., ZhouC., Cao P., Ye C. & Wang B.(2005) Cloning and characterization of a non-TIR-NBS-LRR type diseaseresistance gene analogue from peach. DNA Sequence, 16 (2), 103-110.

18. BaiL., Ye C., Lu J., Yang D., Xue H., Pan Y., CaoP., Wang B., & Liu M. (2009) Ipt gene transformation in petunia by anAgrobacterium mediated method. Journal of Immunoassay and Immunochemistry, 30(2):224-31.


学科建设平台