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高国粉

发布时间:2017-04-18 浏览次数:0

   

   

高国粉

 

教授、硕士生导师

 

联系电话0311-8078758715631123003

 

电子邮件guofen83@hotmail.com

 

所属专业:生理学学习经历:

 

2008--2013年, The Catholic University  of America (美国),细胞与微生物学,PHD. 导师:Venigalla B. Rao.

 

2006--2008年,吉林大学 生命科学学院,微生物与生化药学,硕士。 导师:滕利荣。

 

2002--2006年,吉林大学 生命科学学院,制药工程,本科。

 

主要教学科研工作:

 

教学:属于河北师范大学生命科学学院解剖生理学教研室,承担本科生课程包括《人体及动物生理学》、《组织学与解剖学》、《铁代谢与人类健康》;研究生课程包括《铁代谢分子生物学大实验》。

 

科研方向:(1) 神经退行性疾病的发病机制及治疗策略研究;(2) 铁代谢相关分子调节脑铁平衡的机制研究。

 

所获荣誉:

 

2021年,荣获河北师范大学本科教学质量优秀教师奖;

 

2020年,荣获河北师范大学院处级先进工作者;师德师风考核优秀教师;

 

2019年,荣获河北师范大学本科教学质量优秀教师奖;

 

2018年,入选河北省第三批“青年拔尖人才”支持计划;

 

2018年,荣获河北师范大学本科教学质量优秀教师奖;

 

2016年,荣获河北师范大学本科教学质量优秀教师奖;

 

2015年,荣获河北师范大学生命科学学院青年教师教学技能大赛二等奖;

 

2013年,The Catholic University of America 优秀博士毕业生;

 

承担的主要科研项目:

 

1. 国家自然科学基金-面上项目,2022-2025,主持人。

 

2. 河北省教育厅基金-重点项目,2021-2023,主持人。

 

3. 河北省自然科学基金-面上项目,2019-2022,主持人。

 

4. 河北省教育厅高等学校青年拔尖人才项目,2017-2019,主持人。

 

5. 国家自然科学基金-青年项目,2015-2017,主持人。

 

6. 国家自然科学基金-面上项目,2015-2018,第二参与人。

 

7. 教育部留学归国人员科研启动基金,第48批。2014-2016,主持人。

 

8. 河北省自然科学基金-青年项目,2015-2017,主持人。

 

9. 中国博士后科学基金,项目编号2014M5510442014-2016,主持人。

 

发表的代表性论文:

 

(1) Yi  Zhang, Xiaoqin Gao, Xue Bai, Shanshan Yao, Yan-Zhong Chang*, Guofen Gao*.  The emerging role of furin in neurodegenerative  and neuropsychiatric diseases. Translational Neurodegeneration.  2022, 11: 39

 

(2) Linhao  You, Pan-Pan Yu, Tianyu Dong, Wenhuan Guo, Shiyang Chang, Bingjie Zheng, Yunzhe  Ci, Fudi Wang, Peng Yu, Guofen Gao*, Yan-Zhong Chang*. Astrocyte-derived  hepcidin controls iron traffic at the blood-brain-barrier via regulating  ferroportin 1 of microvascular endothelial cells. Cell Death and  Disease. 2022, 13: 667

 

(3) Yating Zhang,  Xue Bai, Yi Zhang, Shanshan Yao, Yiduo Cui, Lin-Hao You,  Peng Yu*, Yan-Zhong Chang*, Guofen Gao*.  Hippocampal Iron Accumulation Impairs Synapses and Memory  via Suppressing Furin Expression and Downregulating BDNF  Maturation. Molecular Neurobiology. 2022, 59: 5574-5590

 

(4) Kang  Han, Xiaofang Jin, Xin Guo, Guoli Cao, Siyu Tian, Yiming Song, Yuanyuan Zuo,  Peng Yu, Guofen Gao*,  Yan-Zhong Chang*. Nrf2 knockout altered brain iron deposition and mitigated  age-related motor dysfunction in aging mice. Free Radical Biology and Medicine. 2021, 162: 592-602

 

(5) Yong  Xu, Yating Zhang, Jian-Hua Zhang, Kang Han, Xinwei Zhang, Xue Bai, Lin-Hao  You, Peng Yu, Zhenhua Shi, Yan-Zhong Chang*, Guofen Gao*. Astrocyte hepcidin ameliorates neuronal loss  through attenuating brain iron deposition and oxidative stress in APP/PS1  mice. Free Radical Biology and  Medicine. 2020, 158: 84-95

 

(6) Xinwei Zhang,  Yu-Jing Gou, Yating Zhang, Jie Li, Kang Han, Yong Xu, Haiyan Li, Lin-Hao You,  Peng Yu, Yan-Zhong Chang*, Guofen  Gao*. Hepcidin overexpression in astrocytes alters brain iron  metabolism and protects against amyloid-β induced brain damage in mice. Cell Death Discovery. 2020, 6: 113

 

(7) Zhenzhen Liu,  Kang Han, Xuege Huo, Bingqi Yan, Mohan Gao, Xin Lv, Peng Yu, Guofen Gao*, Yan-Zhong Chang*.  Nrf2 knockout dysregulates iron metabolism and increases the hemolysis  through ROS in aging mice. Life  Sciences. 2020, 255: 117838

 

(8) Lan Wang,  Xiaopeng Liu, Lin-Hao You, Yun-Zhe Ci, Shiyang Chang, Peng Yu, Guofen  Gao*, Yan-Zhong Chang*. Hepcidin and iron regulatory proteins  coordinately regulate ferroportin 1 expression in the brain of mice. Journal of Cellular Physiology. 2019, 234: 7600-7607

 

(9) Guofen Gao*, Jie  Li, Yating Zhang, Yan-Zhong Chang*. Cellular Iron Metabolism and Regulation. Advances in Experimental Medicine and  Biology. 2019, 117321-32

 

(10) Guofen Gao, Nan Zhang, Yue-Qi Wang, Qiong Wu, Peng Yu, Zhen-Hua Shi, Xiang-Lin  Duan, Bao-Lu Zhao, Wen-Shuang Wu, Yan-Zhong Chang*. Mitochondrial ferritin  protects hydrogen peroxide-induced neuronal cell damage. Aging & Disease. 2017, 8(4): 458-470.

 

(11) Yaru Li, Peng Yu, Shi-Yang Chang, Qiong Wu, Panpan Yu, Congcong Xie,  Baolu Zhao, Guofen  Gao*,  Yan-Zhong Chang*.  Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats. Journal of Cellular Biochemistry. 2017, 118(6):1596-1605.

 

(12) Yue-Qi Wang, Shang-Yang Chang, Qiong Wu, Yu-Jing Gou, Linpai Jia,  Yan-Mei Cui, Peng Yu, Zhen-Hua Shi, Wen-Shuang Wu, Guofen Gao*, Yan-Zhong Chang*. The protective role of mitochondrial  ferritin on erastin-induced ferroptosis. Frontiers in Aging Neuroscience. 2016, 8:308.

 

(13) Guofen Gao and Yan-Zhong Chang*. Mitochondrial ferritin in the regulation  of brain iron homeostasis and neurodegenerative diseases. Frontiers in Pharmacology. 2014, 5:19

 

(14) Wei-Na Kong, Guofen  Gao, and Yan-Zhong Chang.  Hepcidin and sports anemia, Cell  & Bioscience. 2014,  4(1):19

 

(15) Guofen Gao, Lindsay Wieczorek, Kristina K. Peachman, Victoria R. Polonis, Carl R.  Alving, Mangala Rao, and Venigalla B. Rao*. Designing a soluble near full-length  HIV-1 gp41 trimer. Journal  of Biological Chemistry.  2013, 288(1):234-246

 


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